單分散修飾性PEG、小分子量PEG介紹
在生命科學(xué)領(lǐng)域，上海金畔生物為業(yè)界提供了豐富的實(shí)驗(yàn)室和生物醫(yī)藥生產(chǎn)研發(fā)的產(chǎn)品。上海金畔生物作為成為單分散小分子PEG衍生物性PEG的代理商，在這里要感謝廣大客戶多年來對(duì)上海金畔生物科技有限公司的支持和厚愛，我們將一如既往的為廣大客戶帶來單分散小分子PEG衍生物性PEG高品質(zhì)的產(chǎn)品和服務(wù)，歡迎廣大新老客戶來電咨詢。
聚乙二醇化技術(shù)(PEGylation)是一種先進(jìn)的藥用大分子修飾技術(shù)。聚乙二醇分子與藥物分子連接，能夠增大藥物的相對(duì)分子量，達(dá)到延長藥效，降低毒性，增大藥物的水溶性等效果，聚乙二醇化技術(shù)(PEGylation)是改善藥物臨床效果的重要手段。
Monodisperse PEG（單分散修飾性PEG）的產(chǎn)品一般是由2個(gè)、3個(gè)、4個(gè)PEG重復(fù)單元組成的一種小分子單分散的純的PEG試劑，這類產(chǎn)品的整體分子量較小，他們的分子量的大小跟PEG的重復(fù)個(gè)數(shù)有關(guān)，個(gè)數(shù)越多分子量越大，由于此產(chǎn)品是重復(fù)單元的PEG屬于小分子單體，可以用純度來標(biāo)明其質(zhì)量的好壞，西安瑞禧生物生產(chǎn)的這種產(chǎn)品整體純度一般是95%+以上。該類小分子聚合物的重復(fù)單元一般從1個(gè)到24個(gè)之間不等，PEG二邊也常常存在的不同的基團(tuán)，比如說羧基COOH，NH2氨基，N3疊氮，巰基SH等不同基團(tuán)。當(dāng)然由于該類產(chǎn)品是純的小分子，大部分產(chǎn)品都對(duì)應(yīng)的有自己的CAS號(hào)。
小分子聚乙二醇(PEG)鏈接劑，可用于修飾各類生物藥物，通過正離子親脂類脂質(zhì)體納米顆粒形成配方材料，將可能即時(shí)裝載靶向分子、實(shí)現(xiàn)對(duì)任何藥物的掛載，可為建立針對(duì)腫瘤患者的個(gè)性化治療藥物庫提供成熟的技術(shù)支持。
單分散短鏈小分子PEG
修飾性PEG品牌：金畔生物、Laysan Bio、Nanocs、Sunbio
polymer PEG衍生物產(chǎn)品一般是指以聚合物的聚乙二醇為原料，通過各種化學(xué)鍵反應(yīng)，使得聚合物PEG二邊連上不同的活性基團(tuán)，該類的產(chǎn)品的分子量都比較大，主要也取決于PEG的分子量的大學(xué)，比如說PEG分子量1000，那整體分子量就是1000多一點(diǎn)，如果PEG分子量是2000就是2000多一點(diǎn)，另外整體也看連接的基團(tuán)，比如說PEG分子量是2000 ，他連接了DSPE這個(gè)基團(tuán)，那整體分子量就是2800，如果連接了MAL或者NH2這樣的基團(tuán)，這題分子量就是2100多，該類產(chǎn)品的質(zhì)量不能按純度來衡量，因而PEG是聚合物，整個(gè)產(chǎn)品都是有一個(gè)分子量的分布的，所以該產(chǎn)品應(yīng)該屬于混合物，我們衡量其質(zhì)量一般看2個(gè)指標(biāo)一個(gè)是PDI值，一個(gè)是取代率純度或者叫接枝率，PID值越小PEG的分布越窄，質(zhì)量越好，取代率純度或接枝率越高 說明活性基團(tuán)和PEG的鏈接率越高。該類產(chǎn)品沒有固定的CAS號(hào) 因?yàn)槭蔷酆衔铩?/p>
另外還有一種polymer PEG產(chǎn)品是由二種或者2種以上的聚合物鏈接而成的，我們常常叫嵌段共聚物，A聚合物、B聚合物、C聚合物，我們常見的形式有A-B-A，B-A-B, A-B-C，A-B-C-A
等等，這類產(chǎn)品我們常用的聚合物一般有PEG、PLGA、PLA、PCL、PEI、PLL等等不同產(chǎn)品，往往可以在不同聚合物末端帶有不同的活性基團(tuán)比如說MAL/NHS/COOH等等。
單分散修飾性PEG、小分子量PEG介紹
Monodisperse PEG小分子PEG產(chǎn)品列表：
Amine-PEG2-Acid??? 791028-27-8 ? ?氨基PEG羧基，氨基聚乙二醇羧基
Amine-PEG3-Acid??? 784105-33-5
Amine-PEG4-Acid??? 663921-15-1
Amine-PEG6-Acid??? 905954-28-1
Amine-PEG8-Acid??? 756526-04-2
Thiol-PEG4-Acid? 749247-06-1
Thiol-PEG5-Acid
Thiol-PEG8-Acid? 866889-02-3
Thiol-PEG12-Acid 1032347-93-5
MAL-PEG2-Acid?? ?756525-98-1
MAL-PEG3-Acid??? 518044-40-1
MAL-PEG4-Acid??? 518044-41-2
MAL-PEG5-Acid??? 1286755-26-7
MAL-PEG6-Acid??? 518044-42-3
MAL-PEG8-Acid??? 1818294-46-0
Azido-PEG2-Azide????? 1379365-47-5
Azido-PEG3-azide????? 101187-39-7
Azido-PEG4-Azide????? 182760-73-2
Azido-PEG5-Azide????? 356046-26-9
Biotin-PEG2-Acid??????? 1365655-89-5
Biotin-PEG3-acid??????? 252881-76-8
Biotin-PEG4-Acid??????? 721431-18-1
Biotin-PEG6-Acid??????? 1352814-10-8
Biotin-PEG12-Acid????? 1621423-14-0
Fmoc-NH-PEG2-CH2COOH???? 166108-71-0
Fmoc-NH-PEG2-CH2COOH???? 166108-71-0
Fmoc-NH-PEG3-CH2COOH???? 139338-72-0
Fmoc-NH-PEG4-CH2CO2H????? 437655-95-3
Fmoc-NH-PEG5-CH2COOH???? 635287-26-2
Fmoc-NH-PEG8-CH2COOH???? 868594-52-9
Fmoc-PEG4-NHS ester???? 1314378-14-7
Fmoc-PEG6-NHS ester???? 1818294-31-3
Fmoc-PEG8-NHS ester???? 1334170-03-4
t-Boc-N-amido-PEG2-acid???????? 1365655-91-9
t-Boc-N-amido-PEG3-acid???????? 1347750-75-7
t-Boc-N-amido-PEG4-acid???????? 756525-91-4
t-Boc-N-amido-PEG5-acid???????? 1347750-78-0
t-Boc-N-amido-PEG6-acid???????? 882847-13-4
t-Boc-N-amido-PEG8-acid???????? 1334169-93-5
t-Boc-N-amido-PEG12-acid?????? 187848-68-6
t-Boc-N-amido-PEG2-Amine???? 153086-78-3
t-Boc-N-Amido-PEG3-Amine???? 101187-40-0
t-Boc-N-amido-PEG4-Amine???? 811442-84-9
t-boc-N-amido-PEG5-Amine???? 189209-27-6
t-Boc-N-amido-PEG6-Amine???? 1091627-77-8
t-boc-N-amido-PEG7-Amine???? 206265-98-7
t-Boc-N-amido-PEG9-Amine???? 890091-43-7
t-Boc-N-amido-PEG11-Amine?? 890091-42-6
t-Boc-N-Amido-PEG2-Azide????? 950683-55-3
t-Boc-N-Amido-PEG3-Azide????? 642091-68-7
t-Boc-N-Amido-PEG4-Azide????? 940951-99-5
t-boc-N-amido-PEG5-Azide????? 189209-27-6
mPEG2-NH2? 31576-51-9
mPEG3-NH2? 74654-07-2
mPEG4-NH2? 85030-56-4
mPEG6-NH2? 5498-83-9
mPEG8-NH2? 184357-46-8?? 170572-38-0? 211859-73-3
mPEG9-NH2
mPEG10-NH2??? 854601-60-8
mPEG12-NH2??? 869718-87-6
mPEG3-COOH?? 67319-28-2
mPEG4-COOH?? 81836-43-3
mPEG5-COOH
mPEG6-COOH?? 874208-91-0
mPEG7-COOH?? 1093647-41-6
mPEG3-SH?? 31521-83-2
mPEG4-SH?? 52190-55-3??? 524030-00-0
mPEG6-SH?? 441771-60-4
mPEG8-SH?? 651042-83-0
mPEG9-SH?? 651042-84-1
mPEG10-SH? 651042-85-2
SPDP-PEG3-acid??????? 1334177-97-7
SPDP-PEG6-acid??????? 1818294-33-5
Biotin-PEG3-alcohol??? 1263044-40-1
Biotin-PEG4-alcohol??? 1778736-18-7
Biotin-PEG6-alcohol??? 906099-89-6
Biotin-PEG4-Alkyne??? 1458576-00-5
Biotin-PEG2-Amine???? 138529-46-1
Biotin-PEG3-Amine???? 359860-27-8
Biotin-PEG4-Amine???? 663171-32-2
Biotin-PEG5-Amine???? 113072-75-6
Biotin-PEG2-Azide
Biotin-PEG3-Azide????? 945633-30-7
Biotin-PEG4-Azide????? 875770-34-6
Biotin-PEG5-azide????? 1163732-89-5
Biotin-PEG7-Azide????? 1334172-75-6
NH2-PEG3-NH2??? 929-75-9
NH2-PEG4-NH2??? 68960-97-4
NH2-PEG5-NH2??? 72236-26-1
NH2-PEG6-NH2
NH2-PEG7-NH2
NH2-PEG8-NH2??? 822096-36-7
NH2-PEG9-NH2
NH2-PEG10-NH2??? 928292-69-7
HOOC-PEG3-COOH??? 31127-85-2
HOOC-PEG4-COOH??? 439114-13-3
HOOC-PEG6-COOH??? 94376-75-7
HO-PEG6-COOH?? 1347750-85-9
HO-PEG8-COOH?? 937188-60-8
MAL-PEG2-NHS??? 1433997-01-3
MAL-PEG3-NHS??? 1537892-36-6
MAL-PEG4-NHS??? 1325208-25-0
MAL-PEG5-NHS??? 1807537-42-3
MAL-PEG6-NHS???? 1599472-25-9
H2N-PEG3-OH?? 86770-74-3
H2N-PEG4-OH
H2N-PEG5-OH?? 34188-11-9
H2N-PEG6-OH?? 39160-70-8
H2N-PEG7-OH?? 1425973-14-3
H2N-PEG8-OH?? 352439-37-3
H2N-PEG12-OH?? 933789-97-0
N3-PEG2-NH2?? 166388-57-4
N3-PEG3-NH2?? 134179-38-7
N3-PEG4-NH2?? 951671-92-4
N3-PEG5-NH2?? 516493-93-9
N3-PEG6-NH2?? 957486-82-7
N3-PEG7-NH2? 1333154-77-0
N3-PEG8-NH2? 857891-82-8
N3-PEG10-NH2? 912849-73-1
N3-PEG2-NHS?? 29885-96-9
N3-PEG3-NHS?? 1245718-89-1
N3-PEG4-NHS?? 944251-24-5
N3-PEG5-NHS?? 1433996-86-1
N3-PEG8-NHS?? 1204834-00-3
N3-PEG12-NHS? 1610796-02-5
N3-PEG2-OH??? 139115-90-5
N3-PEG3-OH??? 86520-52-7
N3-PEG4-OH??? 86770-67-4
N3-PEG5-OH?? 86770-68-5
N3-PEG6-OH?? 86770-69-6
N3-PEG2-COOH? 1312309-63-9
N3-PEG3-COOH? 172531-37-2
N3-PEG4-COOH? 1257063-35-6
N3-PEG5-COOH? 1425973-16-5
N3-PEG6-COOH? 361189-66-4
N3-PEG8-COOH? 1214319-92-2
N3-PEG10-COOH? 1644163-57-4
N3-PEG12-COOH ?1167575-20-3
Biotin-PEG2-NH2? 138529-46-1
Biotin-PEG3-NH2? 359860-27-8
Biotin-PEG4-NH2?? 138529-46-1
Biotin-PEG5-NH2?? 113072-75-6
Biotin-PEG6-NH2?? 663171-32-2
Biotin-PEG7-NH2?? 1334172-76-7
Biotin-PEG2-COOH ??1365655-89-5
Biotin-PEG3-COOH ???252881-76-8
Biotin-PEG4-COOH?? 721431-18-1
Biotin-PEG6-COOH?? 1352814-10-8
Biotin-PEG8-COOH
Biotin-PEG12-COOH?? 1621423-14-0
Biotin-PEG3-NHS??? 596820-83-6
Biotin-PEG3-NHS??? 1253286-56-4
Biotin-PEG4-NHS??? 459426-22-3
Biotin-PEG6-NHS
Biotin-PEG8-NHS
Biotin-PEG12-NHS?? 365441-71-0
Biotin-PEG20-NHS
Biotin-PEG24-NHS
Biotin-PEG3-N3?? 945633-30-7
Biotin-PEG4-N3?? 875770-34-6
Biotin-PEG5-N3?? 1163732-89-5
Biotin-PEG7-N3?? 1334172-75-6
Biotin-PEG2-MAL? 305372-39-8
Biotin-PEG3-MAL? 1431618-70-0
Biotin-PEG6-MAL? 1808990-66-0
Biotin-PEG4-Alkyne? 1458576-00-5
Fluorescein-PEG4-Acid?? 1807518-76-8
Fluorescein-PEG6-Acid
Fluorescein-PEG3-Amine? 1807539-04-3
Fluorescein-PEG2-Azide?? 1146195-72-3
Fluorescein-PEG3-(N-Boc)-Amine?? 1807534-77-5
Fluorescein-PEG6-NHS ester?????? 1818294-35-7
TAMRA-PEG3-Azide??? 1228100-59-1
TAMRA-PEG4-Alkyne?? 1225057-68-0
TAMRA-Azide-PEG-Biotin
TAMRA-PEG4-DBCO
Pyrene -PEG4-acid
Pyrene -PEG2-azide
Cy5-PEG4-acid
Mal-PEG2-PFP??? 1807512-47-5
Mal-PEG3-PFP??? 1807534-78-6
Mal-PEG4-PFP??? 1415800-42-8
Mal-PEG5-PFP??? 1807512-46-4
Mal-PEG6-PFP??? 1599486-33-5
Azide-PEG3-Tos? 178685-33-1
Azide-PEG4-Tos? 236754-49-7
Azide-PEG5-Tos? 236754-49-7
Hydroxy-PEG3-Tos?????? 77544-68-4
Hydroxy-PEG4-Tos?????? 77544-68-4
Hydroxy-PEG5-Tos?????? 77544-60-6
Hydroxy-PEG6-Tos?????? 155130-15-7
Propargyl-PEG4-Tos?? 875770-32-4
Propargyl-PEG5-Tos?? 875770-32-4
Azido-PEG3-Maleimide
Bromo-PEG2-azide???? 530151-56-5
Bromo-PEG3-azide???? 940005-81-2
Bromo-PEG5-azide???? 1415800-37-1
Azido-PEG2-TFP ester????? 1807534-87-7
Azido-PEG3-TFP ester????? 1807540-76-6
Azido-PEG4-TFP ester????? 1807505-33-4
Azido-PEG5-TFP ester????? 1807505-31-2
Azido-PEG6-TFP ester????? 1818294-50-6
Azido-PEG8-TFP ester????? 1818294-49-3
Azido-PEG2-PFP ester????? 1393330-37-4
Azido-PEG3-PFP ester????? 1807530-07-9
Azido-PEG4-PFP ester????? 1353012-00-6
Azido-PEG5-PFP ester????? 1818294-48-2
Azido-PEG6-PFP ester????? 1818294-47-1
DBCO-PEG4-acid?????? 1537170-85-6
DBCO-PEG5-Acid
DBCO-PEG4-Alcohol
DBCO-amine??????? 1255942-06-3
DBCO-PEG4-amine??? 1255942-08-5
DBCO-PEG4-Biotin???? 1255942-07-4
DBCO-PEG4-Maleimide???? 1480516-75-3
DBCO-PEG4-NHS ester??? 1427004-19-0
DBCO-PEG5-NHS ester??? 1378531-80-6
DNP-PEG2-acid?? 1353011-89-8
DNP-PEG4-acid?? 858126-76-8
DNP-PEG6-acid?? 1817829-84-7
DNP-PEG4-NHS ester?????? 858126-78-0
propargyl-PEG3-Acid? 1347760-82-0
Propargyl-PEG4-acid? 1415800-32-6
propargyl-PEG5-Acid? 1245823-51-1
Propargyl-PEG2-amine????? 944561-44-8
Propargyl-PEG3-amine????? 932741-18-9
Propargyl-PEG4-amine????? 1013921-36-2
Propargyl-PEG5-amine????? 1589522-46-2
Propargyl-PEG6-amine????? 1198080-04-4
Propargyl-PEG3-azide????????????? 932741-18-9
Propargyl-PEG4-Maleimide?????? 1609651-90-2
Propargyl-PEG3-NHS ester????? 1428629-71-3
Propargyl-PEG4-NHS ester????? 1428629-70-2
Propargyl-PEG5-NHS ester????? 1393330-40-9
DBCO-PEG4-Biotin???? 1255942-07-4
Biotin-PEG3-hydrazide????? 1381861-94-4
Bis-PEG2-acid???? 19364-66-0
Bis-PEG3-acid???? 96517-92-9
Bis-PEG4-acid???? 31127-85-2
Bis-PEG5-acid???? 439114-13-3
Bis-PEG7-acid???? 94376-75-7
Bis-PEG9-acid???? 1268488-70-5
Acid-PEG5-NHS ester????????????? 1343476-41-4
Bis-PEG2-NHS Ester???????? 65869-63-8
Bis-PEG3-NHS Ester???????? 1314378-16-9
Bis-PEG4-NHS ester???????? 1314378-11-4
Bis-PEG5-NHS ester???????? 756526-03-1
Bis-PEG6-NHS ester???????? 1526718-98-8
Bis-PEG7-NHS ester???????? 1334170-02-3
TCO-PEG4-Acid???????? 1802913-21-8
TCO-PEG3-Maleimide?????? 1609659-01-9
TCO-NHS ester????????? 1191901-33-3
TCO-PEG4-NHS ester?????? 1613439-69-2
Hydroxy-PEG2-acid??? 1334286-77-9
Hydroxy-PEG3-acid??? 518044-49-0
Hydroxy-PEG4-acid??? 937188-59-5
Hydroxy-PEG6-acid??? 1347750-85-9
Hydroxy-PEG8-t-butyl ester????? 937188-60-8
Amino-PEG3-alcohol?? 6338-55-2
Amino-PEG4-alcohol?? 86770-74-3
Amino-PEG5-alcohol?? 34188-11-9
Amino-PEG6-alcohol?? 39160-70-8
Amino-PEG7-alcohol?? 1425973-14-3
Amino-PEG8-alcohol?? 352439-37-3
Amino-PEG12-alcohol 933789-97-0
Methyltetrazine-PEG4-Acid?????? 1802907-91-0
Methyltetrazine-PEG5-Alkyne?? 1802907-97-6
Methyltetrazine-PEG4-Amine??? 1802908-05-9
Biotin-PEG4-Methyltetrazine???? 1835759-81-3
Methyltetrazine-PEG4-Maleimide???? 1802908-02-6
Tetrazine-PEG5-NHS ester?????? 1682653-80-0
Methyltetrazine-PEG5-NHS Ester??? 1802907-92-1
Thiol-PEG2-acid? 1379649-73-6
Thiol-PEG3-acid? 1347750-82-6
Thiol-PEG4-acid? 749247-06-1
Thiol-PEG6-acid? 1347750-77-9
Thiol-PEG8-acid? 866889-02-3
Thiol-PEG12-acid????????????? 1032347-93-5
Thiol-PEG3-Alcohol??? 56282-36-1
Thiol-PEG4-Alcohol??? 90952-27-5
Bis-PEG3-thiol???? 2781-02-4
Bis-PEG5-thiol???? 89141-22-0
Lipoamido-PEG4-acid??????? 1314378-10-3
Lipoamido-PEG8-acid??????? 1334172-70-1
Lipoamido-PEG2-alcohol?? 1674386-82-3
Lipoamido-PEG3-alcohol?? 1342764-64-0
Lipoamido-PEG3-Azide????? 890016-39-4
Lipoamide-PEG3-Mal???????? 1314378-19-2
Biotin-PEG3-Lipoamide????? 1311963-67-3
SPDP-PEG6-NHS ester???? 1818294-32-4
Fmoc-N-amido-PEG2-acid??????? 872679-70-4
Fmoc-N-amido-PEG3-acid??????? 867062-95-1
Fmoc-N-amido-PEG4-acid??????? 557756-85-1
Fmoc-N-amido-PEG5-acid??????? 882847-32-7
Fmoc-N-amido-PEG6-acid??????? 882847-34-9
Fmoc-N-amido-PEG8-acid??????? 756526-02-0
Fmoc-N-amido-PEG9-acid??????? 1191064-81-9
Fmoc-N-amido-PEG12-Acid????? 756526-01-9
(+)-Biotin-PEG2-CH2CH2NH2??? 138529-46-1
(+)-Biotin-PEG3-CH2CH2NH2??? 359860-27-8
(+)-Biotin-PEG4-CH2CH2NH2??? 663171-32-2
(+)-Biotin-PEG6-CH2CH2NH2??? N/A
(+)-Biotin-PEG11-CH2CH2NH2? N/A
(+)-Biotin-PEG2-CH2CH2COOH N/A
(+)-Biotin-PEG3-CH2CH2COOH 252881-76-8
(+)-Biotin-PEG4-CH2CH2COOH 721431-18-1
(+)-Biotin-PEG6-CH2CH2COOH N/A
(+)-Biotin-PEG12-CH2CH2COOH????? N/A
(+)-Biotin-PEG2-NHS Ester 596820-83-6
m-PEG2-Azide
m-PEG3-Azide
m-PEG4-Azide
m-PEG6-Azide
m-PEG7-Azide
m-PEG8-Azide