上海金畔代理Lumiprobe品牌活性熒光染料產(chǎn)品

發(fā)表于2024年9月18日由上海金畔生物

Lumiprobe Corporation是美國一家高品質(zhì)生物技術(shù)公司，專業(yè)提供分子生物學(xué)研究用的活性熒光染料。從2006年開始，公司生產(chǎn)并銷售生命科學(xué)研究和診斷學(xué)應(yīng)用的優(yōu)質(zhì)化學(xué)藥品。產(chǎn)品主要有：活性染料(Reactive Dye)和SYBR Green I 染料，用于寡核苷酸合成的亞磷酰胺，點(diǎn)擊化學(xué)用染料和其它試劑。產(chǎn)品主要應(yīng)用：點(diǎn)擊化學(xué)(Click Chemistry)、蛋白質(zhì)組學(xué)研究中的雙向熒光差異凝膠電泳(2D DIGE)和實(shí)時(shí)熒光定量PCR(Realtime PCR)。其中，氨基類染料是包含自由氨基的活性染料，染料可與活化羧酸衍生物和其他親電子的試劑結(jié)合。比如：氨基與EDC-活化的羧基結(jié)合。

? ? 上海金畔生物科技有限公司作為Lumiprobe中國正規(guī)簽約授權(quán)代理商，Lumiprobe上海金畔生物官網(wǎng)：http://lumiprobe.jinpanbio.com/。可提供Lumiprobe產(chǎn)品，產(chǎn)品貨期10個(gè)工作日左右，滿足您的各種科研實(shí)驗(yàn)需求。Lumiprobe產(chǎn)品包括：羧酸類染料、羰基類染料，標(biāo)記分子氨基活性染料，標(biāo)記分子巰基活性染料，動(dòng)物活體成像用染料，蛋白質(zhì)、多肽、核酸等生物分子標(biāo)記染料、點(diǎn)擊化學(xué)等。渠道正規(guī)，質(zhì)量保證，價(jià)格優(yōu)惠。

炔烴 Dye alkynes

1-Ethynyl pyrene
3-Ethynyl perylene
BDP FL alkyne
FAM alkyne, 5-isomer
FAM alkyne, 6-isomer
TAMRA alkyne, 5-isomer
BDP TMR alkyne
Cyanine3 alkyne
Cyanine5 alkyne
Cyanine5.5 alkyne
Cyanine7 alkyne
Cyanine7.5 alkyne
Sulfo-Cyanine3 alkyne
Sulfo-Cyanine5 alkyne

疊氮化物 Dye azides

Pyrene azide 1/ Pyrene azide 2
PEP azide
Perylene azide
BDP FL azide
Coumarin 343 azide
FAM azide, 5-isomer
FAM azide, 6-isomer
TAMRA azide, 5- isomer
BDP TMR azide
Cyanine3 azide
Cyanine3.5 azide
Cyanine5 azide
Cyanine5.5 azide
Cyanine7 azide
Cyanine7.5 azide
Sulfo-Cyanine3 azide
Sulfo-Cyanine5 azide
Sulfo-Cyanine7 azide

N-羥基琥珀酰亞胺脂Dye NHS esters

Pyrenebutyric acid NHS ester
ROX NHS ester, pure 6- isomer
BDP FL NHS ester
FAM NHS ester
Cyanine3 NHS ester
Cyanine3.5 NHS ester
Cyanine5 NHS ester
Cyanine5.5 NHS ester
Cyanine7 NHS ester
Cyanine7.5 NHS ester
Sulfo-Cyanine3 NHS ester
Sulfo-Cyanine5 NHS ester
sulfo-Cyanine5 bis-NHS ester
Sulfo-Cyanine7 NHS ester

馬來酰亞胺 Dye maleimides

Pyrene maleimide
BDP FL maleimide
Cyanine3 maleimide
Cyanine5 maleimide
Cyanine5.5 maleimide
Cyanine7 maleimide
Cyanine7.5 maleimide
Sulfo-Cyanine3 maleimide
Sulfo-Cyanine5 maleimide

伯胺 Primary amine

BDP FL amine
Cyanine3 amine
Cyanine5 amine
Cyanine5.5 amine
Cyanine7 amine
Cyanine7.5 amine
Sulfo-Cyanine5 amine
Sulfo-Cyanine7 amine

酰肼 Dye hydrazides

Pyrene hydrazide
BDP FL hydrazide
Cyanine3 hydrazide
Cyanine5 Boc-hydrazide
Cyanine5 hydrazide
Cyanine5.5 hydrazide
Cyanine7 hydrazide
Cyanine7.5 hydrazide

馬來酰亞胺 Dye maleimides

BDP FL maleimide
Cyanine3 maleimide
Cyanine5 maleimide
Cyanine5.5 maleimide
Cyanine7 maleimide
Cyanine7.5 maleimide
Sulfo-Cyanine3 maleimide
Sulfo-Cyanine5 maleimide

羧酸 Carboxylic acids

Pyrenebutyric acid
BDP FL carboxylic acid
Cyanine3 carboxylic acid
Cyanine3.5 carboxylic acid
Cyanine5 carboxylic acid
Cyanine5.5 carboxylic acid
Cyanine7 carboxylic acid
Cyanine7.5 carboxylic acid
Sulfo-Cyanine3 carboxylic acid
Sulfo-Cyanine5 carboxylic acid
Sulfo-Cyanine7 carboxylic acid

點(diǎn)擊化學(xué)試劑

非熒光炔烴 Non-fluorescent alkynes

Pentynoic acid STP ester
Biotin alkyne

非熒光疊氮化物 Non-fluorescent azides

Azidobutyric acid NHS ester
Biotin azide

寡核苷酸分析

亞磷酰胺 Phosphoramidites

FAM Phosphoramidite, 6-Isomer
Alkyne Amidite, hydroxyprolinol
Alkyne Phosphoramidite, 5′-terminal
DMS(O)MT aminolink C6
Long trebler phosphoramidite
Pyrene phosphoramidite dU

PCR/qPCR PCR/qPCR

ROX reference dye for qPCR
SYBR Green I Gel Staining Solution, 10000x
SYBR Green I for Real Time PCR, 100x

CPG固相修飾 CPG solid supports

Alkyne CPG modifier 500
TFA-Amino modifier CPG 500

三磷酸酯修飾 Modified triphosphates

Amino-11-ddUTP
Amino-11-dUTP

其它試劑

蛋白質(zhì)組學(xué)試劑 Proteomic reagents

3Dye™ 2D DIGE Kits
Cyanine2 NHS ester minimal dye
Cyanine3 NHS ester minimal dye
Cyanine5 NHS ester minimal dye

輔助試劑 Auxiliary reagents

Ascorbic acid
Copper(II)-TBTA complex, 10 mM in 55% aq. DMSO
DMF (dimethylformamide), labeling grade

Lumiprobe Perylene azide熒光染料

發(fā)表于2024年9月16日由上海金畔生物

Lumiprobe Perylene azide熒光染料

Perylene是一種高亮度的且對公極其穩(wěn)定的多環(huán)芳烴（PAH）類熒光染料，其量子產(chǎn)率接近理想化。
因其很短的熒光期，這種探針沒有激發(fā)態(tài)。
因其較低的溶解度和很少量的活性衍生物，Perylene標(biāo)記生物分子通常比較困難且不太容易實(shí)現(xiàn)。然而，通過點(diǎn)擊化學(xué)使用這種perylene azide來進(jìn)行標(biāo)記就變得和其他染料一樣非常容易。使用這種多環(huán)芳烴染料標(biāo)記多肽、DNA、蛋白等從未如此輕松。
為了提高其親水性和標(biāo)記成功率，這種PAH azide包含親水三甘醇鏈。

Perylene is a bright and extremely photostable fluorescent polycyclic aromatic hydrocarbon (PAH) label with quantum yield approaching quantitative.

Due to low life time of fluorescence, this probe does not form excimers.

Perylene labeling of biomolecules is used to be difficult and tedious because of low solubility of perylene, and low availability of activated derivatives. However, labeling via Click Chemistry with this perylene azide is nearly as easy, as with other dyes. Labeling peptide, DNA, protein with this polyaromatic hydrocarbon has never been so simple yet.

To increase hydrophilicity, and facilitate labeling, this PAH azide contains hydrophilic triethyleneglycol linker.

訂購貨號	產(chǎn)品名稱及規(guī)格
A5530	Perylene azide, 1 mg
B5530	Perylene azide, 5 mg
C5530	Perylene azide, 10 mg
D5530	Perylene azide, 25 mg
E5530	Perylene azide, 50 mg

General properties

Appearance:	orange-yellow solid
Molecular weight:	452.50
Molecular formula:	C27H24N4O3
Solubility:	good in dichloromethane and chloroform, moderate in DMSO, DMF, and acetonitrile
Quality control:	NMR 1H (95%) and 13C, TLC, functional testing
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light.
MSDS:	Download

Lumiprobe 23420 BDP TR NHS ester

發(fā)表于2023年10月14日由上海金畔生物

Lumiprobe 23420 BDP TR NHS ester

品牌：Lumiprobe

官方代理商：上海金畔生物科技有限公司（有授權(quán)證書）

歡迎訪問Lumiprobe官網(wǎng)或者咨詢我們獲取更多產(chǎn)品信息。

貨期：僅需要5-7工作日，不需要像其他家攢單導(dǎo)致貨期3-4周。

BDP TR is a bright and photostable borondipyrromethene dye, which is especially suitable for microscopy applications. The dye has a long excited state lifetime, and is therefore is useful for fluorescence polarization assays. Its large two-photon cross section makes this dye useful for two-photon spectroscopy.

This NHS ester is an amine-reactive form of the dye.

Lumiprobe 23420 BDP TR NHS ester

Cat. #	Quantity	Lead time
13420	1 mg	in stock
23420	5 mg	in stock
43420	25 mg	in stock
53420	50 mg	in stock
63420	100 mg	in stock

BDP TR NHS ester structure

Absorption and emission spectra of BODIPY TR

General properties

Appearance:	dark blue-black crystals
Mass spec M+ increment:	406.1
Molecular weight:	521.30
Molecular formula:	C₂₅H₁₈BF₂N₃O₅S
IUPAC name:	Methyl {p-[4,4-difluoro-5-(2-thienyl)-3a,4a-diaza-4-bora-s-indacen-3-yl]phenoxy}acetate
Quality control:	HPLC-MS (95%), UV-Vis
Storage conditions:	Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

Spectral properties

Excitation maximum, nm:	589
ε, L?mol^?1?cm^?1:	69000
Emission maximum, nm:	616
Fluorescence quantum yield:	0.9
CF₂₆₀:	0.15
CF₂₈₀:	0.19

Lumiprobe Bodipy（BDP）活性染料產(chǎn)品列表

BDP 558/568 NHS ester

BDP 581/591 NHS ester

BDP 630/650 X NHS ester

BDP FL NHS ester

BDP R6G NHS ester

BDP TMR NHS ester

BDP TR NHS ester

BDP 558/568 azide

BDP 581/591 azide

BDP 630/650 azide

BDP FL azide

BDP R6G azide

BDP TMR azide

BDP TR azide

BDP 558/568 alkyne

BDP 581/591 alkyne

BDP 630/650 alkyne

BDP FL alkyne

BDP R6G alkyne

BDP TMR alkyne

BDP TR alkyne

BDP 581/591 maleimide

BDP 630/650 maleimide

BDP FL maleimide

BDP R6G maleimide

BDP TMR maleimide

BDP TR maleimide

BDP 581/591 hydrazide

BDP 630/650 hydrazide

BDP FL hydrazide

BDP TR hydrazide

BDP 558/568 carboxylic acid

BDP 581/591 carboxylic acid

BDP 630/650 carboxylic acid

BDP FL carboxylic acid

BDP R6G carboxylic acid

BDP TMR carboxylic acid

BDP TR carboxylic acid

BDP 558/568 carboxylic acid

BDP 581/591 carboxylic acid

BDP 630/650 carboxylic acid

BDP FL carboxylic acid

BDP R6G carboxylic acid

BDP TMR carboxylic acid

BDP TR carboxylic acid

BDP 581/591 tetrazine

BDP 630/650 tetrazine

BDP FL tetrazine

BDP TR tetrazine

BDP 581/591 DBCO

BDP FL DBCO

BDP R6G DBCO

BDP TR methyl ester, 5 mM in DMSO

Lumiprobe 26420 BDP 581/591 NHS ester

發(fā)表于2023年10月14日由上海金畔生物

Lumiprobe 26420 BDP 581/591 NHS ester

品牌：Lumiprobe

官方代理商：上海金畔生物科技有限公司（有授權(quán)證書）

歡迎訪問Lumiprobe官網(wǎng)或者咨詢我們獲取更多產(chǎn)品信息。

貨期：僅需要5-7工作日，不需要像其他家攢單導(dǎo)致貨期3-4周。

Lumiprobe 26420 BDP 581/591 NHS ester

BDP 581/591 is a borondipyrromethene dye that has relatively long fluorescence lifetime and two photon excitation cross section. It is useful for fluorescence polarization assays. Due to the presence of a diene system, it can react with reactive oxygen species (ROS) with a change of fluorescence.

This is the NHS ester derivative for the conjugation with primary and secondary amine groups of proteins, peptides, and other molecules.

Cat. #	Quantity	Lead time
16420	1 mg	in stock
26420	5 mg	in stock
46420	25 mg	in stock
56420	50 mg	in stock
66420	100 mg	in stock

BDP 581/591 NHS ester

Absorption and emission spectra of BDP 581/591

General properties

Appearance:	dark colored solid
Mass spec M+ increment:	374.1
Molecular weight:	489.28
Molecular formula:	C₂₆H₂₂N₃BF₂O₄
Solubility:	good in DMF, DMSO, DCM
Quality control:	NMR ¹H, HPLC-MS (95%)
Storage conditions:	Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

Spectral properties

Excitation maximum, nm:	585
Emission maximum, nm:	594
CF₂₆₀:	0.06
CF₂₈₀:	0.04

Product citations

Tabe, H.; Sukenobe, K.; Kondo, T.; Sakurai, A.; Maruo, M.; Shimauchi, A.; Hirano, M.; Uno, S.-N.; Kamiya, M.; Urano, Y.; Matsushita, M.; Fujiyoshi, S. Cryogenic Fluorescence Localization Microscopy of Spectrally Selected Individual FRET Pairs in a Water Matrix. The Journal of Physical Chemistry B, 2018, 122(27), 6906–6911. doi: 10.1021/acs.jpcb.8b03977

Lumiprobe Bodipy（BDP）活性染料產(chǎn)品列表

發(fā)表于2023年10月14日由上海金畔生物

Lumiprobe Bodipy（BDP）活性染料產(chǎn)品列表

品牌：Lumiprobe

官方代理商：上海金畔生物科技有限公司（有授權(quán)證書）

歡迎訪問Lumiprobe官網(wǎng)或者咨詢我們獲取更多產(chǎn)品信息。

貨期：僅需要5-7工作日，不需要像其他家攢單導(dǎo)致貨期3-4周。

Lumiprobe Bodipy（BDP）活性染料產(chǎn)品列表

BDP 558/568 NHS ester

BDP 581/591 NHS ester

BDP 630/650 X NHS ester

BDP FL NHS ester

BDP R6G NHS ester

BDP TMR NHS ester

BDP TR NHS ester

BDP 558/568 azide

BDP 581/591 azide

BDP 630/650 azide

BDP FL azide

BDP R6G azide

BDP TMR azide

BDP TR azide

BDP 558/568 alkyne

BDP 581/591 alkyne

BDP 630/650 alkyne

BDP FL alkyne

BDP R6G alkyne

BDP TMR alkyne

BDP TR alkyne

BDP 581/591 maleimide

BDP 630/650 maleimide

BDP FL maleimide

BDP R6G maleimide

BDP TMR maleimide

BDP TR maleimide

BDP 581/591 hydrazide

BDP 630/650 hydrazide

BDP FL hydrazide

BDP TR hydrazide

BDP 558/568 carboxylic acid

BDP 581/591 carboxylic acid

BDP 630/650 carboxylic acid

BDP FL carboxylic acid

BDP R6G carboxylic acid

BDP TMR carboxylic acid

BDP TR carboxylic acid

BDP 558/568 carboxylic acid

BDP 581/591 carboxylic acid

BDP 630/650 carboxylic acid

BDP FL carboxylic acid

BDP R6G carboxylic acid

BDP TMR carboxylic acid

BDP TR carboxylic acid

BDP 581/591 tetrazine

BDP 630/650 tetrazine

BDP FL tetrazine

BDP TR tetrazine

BDP 581/591 DBCO

BDP FL DBCO

BDP R6G DBCO

BDP TR methyl ester, 5 mM in DMSO

Lumiprobe BDP FL NHS ester

發(fā)表于2023年10月14日由上海金畔生物

Lumiprobe BDP FL NHS ester

品牌：Lumiprobe

官方代理商：上海金畔生物科技有限公司（有授權(quán)證書）

貨期：僅需要5-7工作日，不需要像其他家攢單導(dǎo)致貨期3-4周。

Lumiprobe BDP FL NHS ester

Cat. #	Quantity	Lead time
11420	1 mg	in stock
			21420	5 mg	in stock
41420	25 mg	in stock
			51420	50 mg	in stock
61420	100 mg	in stock

BDP FL NHS ester is an advanced dye for 488 nm channel, a replacement for fluorescein, a molecule identical to BODIPY FL? NHS ester. An amino-reactive dye for the labeling of proteins and peptides.

While the absorbance and emission spectra of this molecule stay within FAM excitation and emission channels, this dye provides much better photostability, and outstanding brightness. The fluorescence spectrum of BODIPY-FL is narrower than that of FAM. This provides a better brightness for monochromator based instruments, when emission wavelength can be tuned to dye maximum.

The dye is neutral, possesses low molecular weight, and retains high quantum yield in conjugates.

The dye is a good replacement for fluorescein (FAM), BODIPY-FL, Alexa Fluor 488, DyLight 488, Cy2, and other 488 nm dyes.

BDP FL NHS ester

Photo of BDP FL solution

Structure of BODIPY FL NHS ester

Absorption and emission spectra of BDP FL

General properties

Appearance:	orange solid
Mass spec M+ increment:	274.1
Molecular weight:	389.16
CAS number:	146616-66-2
Molecular formula:	C₁₈H₁₈BF₂N₃O₄
Solubility:	Good in organic solvents (DMF, DMSO, dichlromethane), limited in water
Quality control:	NMR ¹H, HPLC-MS (95+%)
Storage conditions:	Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

Spectral properties

Excitation maximum, nm:	503
ε, L?mol^?1?cm^?1:	80000
Emission maximum, nm:	509
Fluorescence quantum yield:	0.97
CF₂₆₀:	0.015
CF₂₈₀:	0.027

Product citations

Poreba, M.; Rut, W.; Vizovisek, M.; Groborz, K.; Kasperkiewicz, P.; Finlay, D.; Vuori, K.; Turk, D.; Turk, B.; Salvesen, G.; Drag, M.Selective imaging of human cathepsin L in breast cancer by fluorescent activity-based probes. Chemical Science, 2018, 9(8), 2113–2129. doi: 10.1039/C7SC04303A
Grube, L.; Dellen, R.; Kruse, F.; Schwender, H.; Stuehler, K.; Poschmann, G. Mining the secretome of C2C12 muscle cells: Data dependent experimental approach to analyze protein secretion using label-free quantification and peptide based analysis. Journal of Proteome Research, 2018, 17(2), 879–890. doi: 10.1021/acs.jproteome.7b00684
Wang, C.; Niederstrasser, H.; Douglas, P.M.; Lin, R.; Jaramillo, J.; Li, Y.; Olswald, N.W.; Zhou, A.; McMillan, E.A.; Mendiratta, S.; Wang, Z.; Zhao, T.; Lin, Z.; Luo, M.; Huang, G.; Brekken, R.A.; Posner, B.A.; MacMillan, J.B.; Gao, J.; White, M.A. Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nature Communications, 2017, 8, 2270. doi: 10.1038/s41467-017-02332-3
Gaspar, I.; Wippich, F.; Ephrussi, A. Enzymatic production of single molecule FISH and RNA capture probes. RNA, 2017, 23(10), 1582–1591. doi: 10.1261/rna.061184.117

Bodipy(BDP)氟硼熒光活性染料發(fā)展歷史

Bodipy二吡咯類熒光染料相對比于熒光素、羅丹明或者菁染料有著較高的選擇性、高靈敏度、高熒光量子產(chǎn)率、高摩爾消光系數(shù)、良好的光學(xué)穩(wěn)定性和對PH不敏感的優(yōu)點(diǎn)被廣泛應(yīng)用于生物標(biāo)記、熒光探針及生物成像，西安瑞禧生物科技有限公司可以提供種類豐富的Bodipy熒光染料，熒光波長可定制從550-800之間，末端可以修飾各種活性基團(tuán)。

Bodipy類熒光染料具有良好的穩(wěn)定性、優(yōu)良的光學(xué)性能，主要表現(xiàn)在以下幾個(gè)方面：

1：BODIPY的光譜峰寬比較窄，在光學(xué)領(lǐng)域和生物學(xué)領(lǐng)域進(jìn)行分析檢測時(shí)，光譜峰寬較窄，檢測靈敏度較高，并且減少了待測樣品的用量。測得的結(jié)果中，熒光光譜上會出現(xiàn)更為明顯的熒光吸收和發(fā)射的變化，這樣更精確地測得了樣品的含量。

2：在整個(gè)BODIPY分子中，并不存在負(fù)電荷。因而在溶液中，溶液中的離子無法與缺少電荷的BODIPY分子發(fā)生靜電作用，這樣非常有效的避免了測定時(shí)靜電作用對測量結(jié)果的干擾，使測定過程更加穩(wěn)定，測得結(jié)果更加精準(zhǔn)。

3：BODIPY類熒光染料的光穩(wěn)定性能非常優(yōu)越，當(dāng)它被激發(fā)到達(dá)激發(fā)態(tài)時(shí)，不會因?yàn)楹荛L時(shí)間的激發(fā)而在分析測定過程中發(fā)生激發(fā)態(tài)的分解或其他變化，這樣測得的熒光光譜更加準(zhǔn)確可信。

4：BODIPY染料，其熒光量子產(chǎn)率甚至接近1.0。一般普通的染料在水溶液中其熒光量子產(chǎn)率會變低，有的甚至被猝滅。對于BODIPY分子來說，在水溶液中其熒光量子產(chǎn)率雖然有所下降，但它仍然能保持較高的熒光量子產(chǎn)率。

5：由BODIPY的母體結(jié)構(gòu)可知，他的母體結(jié)構(gòu)上的取代基一般不會出現(xiàn)氨基或羧基這類對酸堿敏感的活性基團(tuán)。因此外界的酸堿度對其影響會大幅度減小，因此BODIPY染料不會輕易變質(zhì)。

6：BODIPY類熒光染料對光的感應(yīng)度很高，并且它還有高的摩爾消光系數(shù)，有些經(jīng)過修飾后的BODIPY染料在水溶液中的溶解度也較高，再加上它在水中不易被猝滅這一優(yōu)異的性能，使得BODIPY在光學(xué)、生物學(xué)、分析學(xué)領(lǐng)域有著極其廣泛的應(yīng)用。

西安瑞禧生物科技有限公司可以提供激發(fā)和發(fā)射波長從500nm-800nm的活性染料（包括800nm左右的近紅外）并且可以修飾NHS、MAL、NH2、COOH、N3、SH等不同活性基團(tuán)。

常規(guī)的Bodipy熒光染料都是激發(fā)發(fā)射波長都是在500-650nm之間的，包括國外的商家也只能提供500-650nm波長的熒光染料，瑞禧生物不僅可以提供波長在500-600nm之間的波長還可以提供650-800nm之間的近紅外波段的BDP

500-800之間的波長可以選擇：
Bodipy carboxylic acid（羧基COOH）
Bodipy NHS ester（活化脂NHS）
Bodipy amine （NH2氨基）
Bodipy maleimide （MAL馬來酰亞胺）
Bodipy azide （N3疊氮）
Bodipy alkyne （ALK炔烴）
Bodipy hydrazide （HZ酰基）
Bodipy Thiol （HS巰基）

產(chǎn)品列表：
BODIPY™ FL NHS Ester (Succinimidyl Ester)
BODIPY™ FL Sulfonated Succinimidyl Ester
BODIPY™ FL-X NHS Ester (Succinimidyl Ester)
BODIPY™ TMR-X NHS Ester (Succinimidyl Ester)
BODIPY™ 530/550 NHS Ester (Succinimidyl Ester)
BODIPY™ R6G NHS Ester (Succinimidyl Ester)
BODIPY™ 581/591 NHS Ester (Succinimidyl Ester)
BODIPY™ 576/589 NHS Ester (Succinimidyl Ester)
BODIPY™ 650/665-X NHS Ester (Succinimidyl Ester)
BODIPY™ 493/503 NHS Ester (Succinimidyl Ester)
BODIPY™ 558/568 NHS Ester (Succinimidyl Ester)
BODIPY™ TR-X NHS Ester (Succinimidyl Ester)
BODIPY™ 630/650-X NHS Ester (Succinimidyl Ester)
BODIPY™ FL maleimide
BODIPY™ FL azide
BODIPY™ FL alkyne
BODIPY™ FL hydrazide
BODIPY™ FL amine
BODIPY™ FL Carboxylic acid
BODIPY™ TR ceramide
BODIPY™ FL STP ester
BODIPY™ FL C12-sphingomyelin
BODIPY™ R6G NHS Ester
BODIPY™ 558/568 phalloidin
BODIPY™ FL hydrazide
BODIPY™ TMR-X NHS Ester
BODIPY™ FL L-cystine
BODIPY™ FL Carboxylic acid
BODIPY™ FL Carboxylic acid
BODIPY™ FL Carboxylic acid

BODIPY?493/503 NHS ester
BODIPY?493/503 Carboxylic acid
BODIPY?493/503 amine
BODIPY?493/503 maleimide
BODIPY?493/503 azide
BODIPY?493/503 alkyne

BODIPY?558/568 NHS ester
BODIPY?558/568 Carboxylic acid
BODIPY?558/568 amine
BODIPY?558/568 maleimide
BODIPY?558/568 azide
BODIPY?558/568 alkyne

BODIPY?650/665 NHS ester
BODIPY?650/665 Carboxylic acid
BODIPY?650/665 amine
BODIPY?650/665 maleimide
BODIPY?650/665 azide
BODIPY?650/665 alkyne

BODIPY?FL NHS Ester
BODIPY?TMR NHS Ester
BODIPY?TR NHS Ester
BODIPY?FL amine
BODIPY?TMR amine
BODIPY?TR amine

?
以下染料的激發(fā)波長是685nm 發(fā)射波長是720nm
Azo-Bodipy-685? (ABDP685)
Azo-Bodipy 685 carboxylic acid
Azo-Bodipy 685 azide
Sulfo-Azo-Bodipy 685 azide
Sulfo-Azo-Bodipy 685 carboxylic acid
Azo-Bodipy 685 NHS ester
Sulfo-Azo-Bodipy 685 NHS ester
Azo-Bodipy 685 amine
Sulfo-Azo-Bodipy 685 amine
PEG-Azo-Bodipy 685 NHS ester
PEG- Azo-Bodipy 685 amine
Azo-Bodipy 685 alkyne
Sulfo-Azo-Bodipy 685 alkyne
Azo-Bodipy 685 azide
Sulfo-Azo-Bodipy 685 azide
Azo-Bodipy 685 maleimide
Sulfo-Azo-Bodipy 685 maleimide
Azo-Bodipy 685 pH6.5

我們還接受激發(fā)波長和發(fā)射波長在500nm-800nm之間的BDP活性熒光染料的定制產(chǎn)品。
上面所述染料可以連接：COOH,? NH₂,? NHS,? MAL,? N₃,? ALK,? hydrazide,? SH

其他波長的BDP活性染料的產(chǎn)品列表：
產(chǎn)品列表：
BDP 558/568 NHS ester
BDP 581/591 NHS ester
BDP 630/650 X NHS ester
BDP FL NHS ester
BDP R6G NHS ester
BDP TMR NHS ester
BDP TR NHS ester

BDP 581/591 azide
BDP 630/650 azide
BDP FL azide
BDP R6G azide
BDP TMR azide
BDP TR azide

BDP 558/568 alkyne
BDP 581/591 alkyne
BDP 630/650 alkyne
BDP FL alkyne
BDP R6G alkyne
BDP TMR alkyne
BDP TR alkyne

BDP 581/591 maleimide
BDP 630/650 maleimide
BDP FL maleimide
BDP R6G maleimide
BDP TMR maleimide
BDP TR maleimide

BDP 581/591 hydrazide
BDP 630/650 hydrazide
BDP FL hydrazide
BDP TR hydrazide

BDP 558/568 carboxylic acid
BDP 581/591 carboxylic acid
BDP 630/650 carboxylic acid
BDP FL carboxylic acid
BDP R6G carboxylic acid
BDP TMR carboxylic acid
BDP TR carboxylic acid

BDP 581/591 amine
BDP 630/650 amine
BDP FL amine
BDP R6G amine
BDP TMR amine
BDP TR amine

BDP 581/591 tetrazine
BDP 630/650 tetrazine
BDP FL tetrazine
BDP TR tetrazine

BODIPY母體結(jié)構(gòu)最初是由德國化學(xué)家Treibs, A.和kreuzer, F. H.在1968年合成的，他們合成的BODIPY 類熒光染料 [40] 。另外，他們還合成了BODIPY染料的母體結(jié)構(gòu)。在BODIPY母體結(jié)構(gòu)中，Treibs, A.和kreuzer, F. H.在R1-R7中用不同基團(tuán)取代得到不同的衍生產(chǎn)物。人們根據(jù)Treibs, A.和kreuzer, F. H.的前期探索，對BODIPY類染料做出了多種結(jié)構(gòu)修飾，這大大豐富了BODIPY的種類，使其迅猛發(fā)展。

Lumiprobe Cy5.5羧酸 Cyanine5.5 carboxylic acid

發(fā)表于2023年9月23日由上海金畔生物

Lumiprobe Cy5.5羧酸 Cyanine5.5 carboxylic acid

英文名：Cyanine5.5 carboxylic acid
級別：NMR 1H (95%) and 13C， TLC
分子式：C40H43ClN2O2
分子量：619.23
品牌：lumiprobe
CAS：1144107-80-1， 1256349-47-9
外觀：dark blue powder

訂購貨號	產(chǎn)品名稱及規(guī)格
17090	Cyanine5.5 carboxylic acid, 1 mg
27090	Cyanine5.5 carboxylic acid, 5 mg
47090	Cyanine5.5 carboxylic acid, 25 mg
57090	Cyanine5.5 carboxylic acid, 50 mg
67090	Cyanine5.5 carboxylic acid, 100 mg

Cyanine5.5 dye，游離酸形式，非活性染料。該染料對大多數(shù)應(yīng)用可以理解為非活性。它可以用作對照或參考樣本，和對儀器進(jìn)行校準(zhǔn)。
預(yù)活化的NHS ester染料可以用于氨基基團(tuán)的標(biāo)記。Cy? is a trademark of GE Healthcare.General properties

Appearance:	dark blue powder
Molecular weight:	619.23
Molecular formula:	C₄₀H₄₃ClN₂O₂
CAS number:	1144107-80-1, 1256349-47-9
Solubility:	soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control:	NMR 1H (95%) and 13C, TLC
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	Download

Spectral properties

Excitation maximum, nm:	673
Extinction coefficient at excitation maximum, Lmol-1cm-1:	209000
Emission maximum, nm:	707
Fluorescence quantum yield:	0.2

Product citations

Camerino, M.A.; Liu, M.; Moriya, S.; Kitahashi, T.; Mahgoub, A.; Mountford, S.J.; Chalmers, D.K.; Soga, T.; Parhar, I.S.; Thompson, P.E.?Beta amino acid-modified and fluorescently labelled kisspeptin analogues with potent KISS1R activity.?Journal of Peptide Science,?2016, 22(6), 406–414. doi:?10.1002/psc.2883

Zhao, Y.; Fay, F.; Hak, S.; Manuel Perez-Aguilar, J.; Sanchez-Gaytan, B.L.; Goode, B.; Duivenvoorden, R.; de Lange Davies, C.; Bj?rk?y, A.; Weinstein, H.; Fayad, Z.A.; Pérez-Medina, C.; Mulder, W.J.M.?Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy.?Nature Communications,?2016, 7, 11221. doi:?10.1038/ncomms11221

Kwok, S.J.J.; Choi, M.; Bhayana, B.; Zhang, X.; Ran, C.; Yun, S.-H.?Two-photon excited photoconversion of cyanine-based dyes.Scientific Reports,?2016, 6, 23866. doi:?10.1038/srep23866

Wang, X.; Wang, C.; Zhang, Q.; Cheng, Y.?Near Infrared Light-responsive and Injectable Supramolecular Hydrogels for On-demand Drug Delivery.?Chemical Communications,?2016, 52, 978–981. doi:?10.1039/c5cc08391e
Kim, K.S.; Park, W.; Hu, J.; Bae, Y.H.; Na, K.?A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle.Biomaterials,?2014, 35(1), 337-343. doi:?10.1016/j.biomaterials.2013.10.004

Lee, B.-S.; Amano, T.; Wang, H.Q.; Pantoja, J.L.; Yoon, C.W.; Hanson, C.J.; Amatya, R.; Yen, A.; Black, K.L.; Yu, J.S.?Reactive Oxygen Species Responsive Nanoprodrug to Treat Intracranial Glioblastoma.?ACS Nano,?2013, 7(4), 3061-3077. doi:10.1021/nn400347j

Cy5.5馬來酰亞胺–標(biāo)記分子巰基的活性染料

發(fā)表于2023年9月23日由上海金畔生物

Cy5.5馬來酰亞胺–標(biāo)記分子巰基的活性染料

Cy5.5馬來酰亞胺 ?Cyanine5.5 maleimide

Cy5.5馬來酰亞胺是巰基活性染料，可以標(biāo)記蛋白的巰基。近紅外Cy5.5可用于小動(dòng)物成像。
Cy5.5可以代替Alexa Fluor 680，DyLight 680

分子結(jié)構(gòu)：

一般性質(zhì)：
外觀：深藍(lán)色粉末
分子量：741.36
分子式：C46H49ClN4O3
溶解性：溶于有機(jī)溶劑（DMSO,DMF,二氯甲烷），略溶于水
質(zhì)控：NMR 1H（95%）和13C,TLC,功能測試光譜性質(zhì)：
最大激發(fā)波長：673nm
最大激發(fā)波長下的消光系數(shù)：209000Lmol^-1cm^-1
最大發(fā)射波長：707nm
熒光量子產(chǎn)率：0.2

Cy5馬來酰亞胺 ?Cyanine5.5 maleimide

Cy5馬來酰亞胺是標(biāo)記多肽和蛋白巰基的活性染料，此染料可與多種設(shè)備兼容，比如顯微鏡，成像儀和熒光讀數(shù)儀。分子結(jié)構(gòu)：

一般性質(zhì)：
外觀：深藍(lán)色粉末
分子量：641.24
分子式：C38H45ClN4O3
溶解性：溶于有機(jī)溶劑（DMF,DMSO,二氯甲烷），不溶于水
質(zhì)控：NMR 1H（95%）和13C,TLC,功能測試光譜特性：
最大激發(fā)波長：646nm
在最大激發(fā)波長下的消光系數(shù)：250000Lmol^-1cm^-1
最大激發(fā)波長：662nm
熒光量子產(chǎn)率：0.2

Cy3馬來酰胺 ?Cyanine3 maleimide

巰基活性Cy3染料，可以將Cy3熒光團(tuán)結(jié)合到蛋白和多肽的巰基上。分子結(jié)構(gòu)：

一般性質(zhì)：
外觀：紅色粉末
分子量：615.2
分子式：C36H43ClN4O3
溶解性：溶于有機(jī)溶劑（DMF，DMSO，二氯甲烷），不溶于水
質(zhì)控：NMR 1H（95%）和13C,TLC，功能測試光譜性質(zhì)：
最大激發(fā)波長：555nm
在最大激發(fā)波長下的消光系數(shù)：150000Lmol^-1cm^-1
最大發(fā)射波長:570nm
熒光量子產(chǎn)率：0.31

Cy7馬來酰亞胺 ??Cyanine7 maleimide

近紅外，巰基活性Cy7染料。此試劑可將近紅外的Cy7染料連接到蛋白的巰基上，標(biāo)記的蛋白可以用于近紅外生物成像。分子結(jié)構(gòu)：

一般性質(zhì)：
外觀：綠色粉末
分子量：707.34
分子式：C43H51ClN4O3
溶解性：易溶于DMF,DMSO，二氯甲烷，不易溶于水
質(zhì)控：NMR 1H(95%)13C,TLC,功能測試光譜性質(zhì)：
最大激發(fā)波長：750nm
在最大激發(fā)波長下的消光系數(shù)：199000Lmol^-1cm^-1
最大發(fā)射波長：773nm
熒光量子產(chǎn)率：0.3

Cy7.5馬來酰亞胺 ?Cyanine7.5 maleimide

巰基活性，近紅外染料Cy7.5用于標(biāo)記生物分子的巰基。
多數(shù)蛋白含有巰基，可由馬來酰亞胺進(jìn)行選擇性標(biāo)記。使用此試劑，這些蛋白可以轉(zhuǎn)化為近紅外熒光素結(jié)合物。標(biāo)記后的復(fù)合物可以用于活體動(dòng)物成像，研究組織和器官中蛋白的分配。分子結(jié)構(gòu)：

一般性質(zhì)：
外觀：綠色粉末
分子量：807.46
分子式：C51H55ClN4O3
溶解性：易溶于DMF,DMSO，二氯甲烷，不易溶于水
質(zhì)控：NMR 1H(95%)13C,TLC,功能測試
保存條件：保存：-20℃，避光保存24個(gè)月。運(yùn)輸：常溫下最多3周，避光，干燥。光譜性質(zhì)：
最大激發(fā)波長：788nm
在最大激發(fā)波長下的消光系數(shù)：223000Lmol^-1cm^-1
最大發(fā)射波長：808nm

Cy5.5馬來酰亞胺–標(biāo)記分子巰基的活性染料

Lumiprobe cy7.5馬來酰亞胺|Cyanine7.5 maleimide

發(fā)表于2023年9月23日由上海金畔生物

Lumiprobe cy7.5馬來酰亞胺|Cyanine7.5 maleimide

英文名：Cyanine7.5 maleimide
級別：NMR 1H (95%) and 13C， TLC， functional testing
分子式：C51H55ClN4O3
分子量：807.46
品牌：lumiprobe
外觀：green powder

訂購貨號	產(chǎn)品名稱及規(guī)格
16080	Cyanine7.5 maleimide, 1 mg
26080	Cyanine7.5 maleimide, 5 mg
46080	Cyanine7.5 maleimide, 25 mg
56080	Cyanine7.5 maleimide, 50 mg
66080	Cyanine7.5 maleimide, 100 mg

硫醇活性染料、近紅外Cyanine7.5，用于標(biāo)記蛋白的巰基基團(tuán)，是Cy7.5? maleimide的類似物。
大多數(shù)蛋白含有巰基基團(tuán)，可以選擇性的標(biāo)記馬來酰亞胺。該試劑可以使這些蛋白連接上近紅外熒光團(tuán)。然后，該復(fù)合物可以用于非入侵性的活體成像，來研究組織和生物體內(nèi)的蛋白分布。

推薦手冊：

蛋白與其他硫醇分子的馬來酰亞胺標(biāo)記

Cy? is a trademark of GE Healthcare.

General properties

Appearance:	>green powder
Molecular weight:	>807.46
Molecular formula:	C₅₁H₅₅ClN₄O₃
Solubility:	>soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control:	>NMR 1H (95%) and 13C, TLC, functional testing
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	Download

Spectral properties

Excitation maximum, nm:	788
Extinction coefficient at excitation maximum, Lmol-1cm-1:	223000
Emission maximum, nm:	808

Lumiprobe Cy7.5-N-羥基琥珀酰亞胺酯

發(fā)表于2023年9月23日由上海金畔生物

Lumiprobe Cy7.5-N-羥基琥珀酰亞胺酯

英文名：Cyanine7.5 NHS ester
分子式：C49H52ClN3O4
分子量：782.41
品牌：lumiprobe
外觀：green powder

訂購貨號	產(chǎn)品名稱及規(guī)格
16020	Cyanine7.5 NHS ester, 1 mg
26020	Cyanine7.5 NHS ester, 5 mg
46020	Cyanine7.5 NHS ester, 25 mg
56020	Cyanine7.5 NHS ester, 50 mg
66020	Cyanine7.5 NHS ester, 100 mg

Cyanine7.5是一種近紅外熒光染料，具有很長的發(fā)射光譜，是此類熒光衍生而來的活性胺產(chǎn)品。近紅外照射很容易穿透組織因此常應(yīng)用于體內(nèi)成像領(lǐng)域。該產(chǎn)品可以用于標(biāo)記含有氨基的小分子物質(zhì)，比如蛋白和多肽，通過近紅外光譜成像技術(shù)（NIR imaging）來示蹤他們在有機(jī)體內(nèi)的分布。中心聚亞甲基基團(tuán)的增強(qiáng)的穩(wěn)定性使得量子產(chǎn)率較其母結(jié)構(gòu)Cy7.5? NHS提高20%。

推薦手冊氨基分子的NHS酯標(biāo)記

Cy? is a trademark of GE Healthcare.

General properties

Appearance:	green powder
Molecular weight:	782.41
Molecular formula:	C₄₉H₅₂ClN₃O₄
Solubility:	soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control:	NMR 1H (95%) and 13C, TLC, functional testing
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	Download

Spectral properties

Excitation maximum, nm:	788
Extinction coefficient at excitation maximum, Lmol-1cm-1:	223000
Emission maximum, nm:	808

Product citations

Zhang, Z.; Cai, H.; Liu, Z.; Yao, P.?Effective Enhancement of Hypoglycemic Effect of Insulin by Liver-targeted Nanoparticles Containing Cholic Acid-modified Chitosan Derivative.?Molecular Pharmaceutics, in press. doi:10.1021/acs.molpharmaceut.6b00188

Dou, Y.; Guo, J.; Chen, Y.; Han, S.; Xu, X.; Shi, Q.; Jia, Y.; Liu, Y.; Deng, Y.; Wang, R.; Li, X.; Zhang, J.?Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice.?Journal of Controlled Release,?2016, 235, 48–62. doi:?10.1016/j.jconrel.2016.05.049

Markovic, S.; Belz, J.; Kumar, R.; Cormack, R.A.; Sridhar, S.; Niedre, M.?Near-infrared fluorescence imaging platform for quantifying?in vivo?nanoparticle diffusion from drug loaded implants.?International Journal of Nanomedicine,?2016, 11, 1213–1223. doi:?10.2147/IJN.S93324

Han, F.Y.; Thurecht, K.J.; Lam, A.-L.; Whittaker, A.K.; Smith, M.T.?Novel Polymeric Bioerodable Microparticles for Prolonged-Release Intrathecal Delivery of Analgesic Agents for Relief of Intractable Cancer-Related Pain.?Journal of Pharmaceutical Sciences,?2015, 104(7), 2334–2344. doi:?10.1002/jps.24497
Duong, H.T.T.; Dong, Z.; Su, L; Boyer, C.; George, J.; Davis, T.P.; Wang, J.?The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension.?Small,?2015, 11(19), 2291–2304.201402870
Chen, K.; Xu, X.; Guo, J.W.; Zhang, X.; Han, S.; Wang, R.; Li, X.; Zhang, J.?Enhanced Intracellular Delivery and Tissue Retention of Nanoparticles by Mussel-Inspired Surface Chemistry.?Biomacromolecules,?2015, 16(11), 3574–3583. doi:10.1021/acs.biomac.5b01056
Lin, Y.-A.; Cheetham, A.G.; Zhang, P.; Ou, Y.-C.; Li, Y.; Liu, G.; Hermida Merino, D.; Hamley, I.W.; Cui, H.?Multi-Walled Nanotubes Formed by Catanionic Mixtures of Drug Amphiphiles.?ACS Nano,?2014, 8(12), 12690-12700. doi:?10.1021/nn505688b
Graen, T.M.D.; Hoefling, M.; Grubmüller, H.?AMBER-DYES: Characterization of Charge Fluctuations and Force Field Parameterization of Fluorescent Dyes for Molecular Dynamics Simulations.?Journal of Chemical Theory and Computation,?2014, 10(12), 5505-5512. doi:?10.1021/ct500869p
Lu, H.D.; Soranno, D.E.; Rodell, C.B.; Kim, I.L.; Burdick, J.A.?Secondary Photocrosslinking of Injectable Shear-Thinning Dock-and-Lock Hydrogels.?Advanced Healthcare Materials,?2013, 2(7), 1028-1036. doi:?10.1002/adhm.201200343
Yang, H.; Mao, H.; Wan, Z.; Zhu, A.; Guo, M.; Li, Y.; Li, X.; Wan, J.; Yang, X.; Shuai, X. et al.?Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy.?Biomaterials,?2013, 34(36), 9124-9133. doi:?10.1016/j.biomaterials.2013.08.022